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T. L. Chester, “The Role of Supercritical Fluid Chromatography in Analytical Chemistry,” Journal of Chromatographic Science, Vol. 24, No. 6, 1986, pp. 226-229. doi:10.1093/chromsci/24.6.226

has been cited by the following article:

• TITLE: Isolation and Characterization of R-Enantiomer in Ezetimibe

  AUTHORS: Kameswararao Chimalakonda, Venugopal Kamani, Madhusudhan Gutta, Srinivasulu Polisetty, Sai Venkata Srinivas Koduri

  KEYWORDS: Isolation; Characterization; (R)-Isomer; Ezetimibe; Supercritical Fluid Hromatography (SFC)

  JOURNAL NAME: American Journal of Analytical Chemistry, Vol.4 No.9, September 13, 2013

  ABSTRACT: A simple and rapid Supercritical Fluid Chromatography (SFC) method has been developed to isolate and characterize R-Isomer of Ezetimi be by using normal phase Chiral Cel OD-H with 250 mm × 30 mm, 5 microns column using a mobile phase system containing super critical fluid carbondi oxide (Co2) and the percentage of 2-Propanol as a mobile phase (85:15) and detection at 230 nm. The isolated R-Isomer is characterized by using UV-vis, FT-IR, ESI-MS, HPLC1H and 13C NMR. The purity of isolated R-Isomer is about 98%.