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M. Von Heek, C. Farley and D. S. Compton, “Ezetimibe Selectively Inhibits Intestinal Cholesterol Absorption in Rodents in Presence and Absence of Exocrine Pancreatic Function,” British Journal of Pharmacology, Vol. 134, No. 2, 2001, pp. 409-417.

has been cited by the following article:

• TITLE: Isolation and Characterization of R-Enantiomer in Ezetimibe

  AUTHORS: Kameswararao Chimalakonda, Venugopal Kamani, Madhusudhan Gutta, Srinivasulu Polisetty, Sai Venkata Srinivas Koduri

  KEYWORDS: Isolation; Characterization; (R)-Isomer; Ezetimibe; Supercritical Fluid Hromatography (SFC)

  JOURNAL NAME: American Journal of Analytical Chemistry, Vol.4 No.9, September 13, 2013

  ABSTRACT: A simple and rapid Supercritical Fluid Chromatography (SFC) method has been developed to isolate and characterize R-Isomer of Ezetimi be by using normal phase Chiral Cel OD-H with 250 mm × 30 mm, 5 microns column using a mobile phase system containing super critical fluid carbondi oxide (Co2) and the percentage of 2-Propanol as a mobile phase (85:15) and detection at 230 nm. The isolated R-Isomer is characterized by using UV-vis, FT-IR, ESI-MS, HPLC1H and 13C NMR. The purity of isolated R-Isomer is about 98%.