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L. T. Guey, J. Kravic, O. Melander, N. P. Burtt, J. M. Laramie, V. Lyssenko, A. Jonsson, E. Lindholm, T. Tuomi, S. Isomaa, P. Nilsson, P. Almgren, S. Kathiresan, L. Groop, A. B. Seymour, D. Altshuler and B. F. Voight, “Power in the Phenotypic Extremes: A Simulation Study of Power in discovery and Replication of Rare Variants,” Genetic Epidemiology, Vol. 35, No. 4, 2011, pp. 236-246.

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• TITLE: Symptom Cluster Research in Women with Breast Cancer: A Comparison of Three Subgrouping Techniques

  AUTHORS: Angela R. Starkweather, Debra E. Lyon, R. K. Elswick Jr., Alison Montpetit, Yvette Conley, Nancy L. McCain

  KEYWORDS: Breast Neoplasms; Cluster Analysis; Symptom Clusters; Psychoneurological Symptoms

  JOURNAL NAME: Advances in Breast Cancer Research, Vol.2 No.4, September 9, 2013

  ABSTRACT: Aims: To examine how symptom cluster subgroups defined by extreme discordant composite scores, cut-off scores, or a median split influence statistical associations with peripheral cytokine levels in women with breast cancer. Background: Systemic cytokine dysregulation has been posited as a potential biological mechanism underlying symptom clusters in women with breast cancer. Symptom characteristics may play an important role in identifying cytokines of significant etiological importance, however, there is no consensus regarding to the ideal subgrouping technique to use. Design: A secondary analysis of data collected from a cross-sectional descriptive study of women with stage I-II breast cancer was used to examine and compare the relationships between peripheral cytokine levels and symptom subgroups defined by extreme discordant composite scores, cut-off scores, or a median split. Methods: Participant symptom scores were transformed into a composite score to account for variability in symptom intensity, frequency and interference. Cytokine levels in subgroups defined by composite scores within the highest and lowest 20% were contrasted with those composed from cut-off scores and a median split. Results: Subgroups defined by the composite score or cut-off scores resulted in similar statistical relationships with cytokine levels in contrast to the median split technique. The use of a median split for evaluating relationships between symptoms clusters and cytokine levels may increase the risk of a type I error. Conclusion: Composite and cut-off scores represent best techniques for defining symptom cluster subgroups in women with breast cancer. Using a consistent approach to define symptom clusters across studies may assist in identifying relevant biological mechanisms.