TITLE:
Serum Omega-6/Omega-3 Ratio and Risk Markers for Cardiovascular Disease in an Industrial Population of Delhi
AUTHORS:
Ruby Gupta, Ramakrishnan Lakshmy, Ransi Ann Abraham, Kolli Srinath Reddy, Panniyammakal Jeemon, Dorairaj Prabhakaran
KEYWORDS:
Omega Fatty Acids; Dyslipidemia; Omega 6/3 Ratio; CHD, hs CRP
JOURNAL NAME:
Food and Nutrition Sciences,
Vol.4 No.9A,
August
30,
2013
ABSTRACT: High omega-6/omega-3 ratio
intake promotes development of many chronic diseases. Secondary prevention
studies though have demonstrated a decline in progression of many such diseases
after reducing the intake, specific biochemical indices of cardiovascular
disease risk markers have not been evaluated. We have evaluated the circulating
levels of omega-6/omega-3 ratio and its effect on cardiovascular risk markers in
India. Present study was conducted in industrial setting where employees were randomly
selected. Data on their demographic characteristics were collected using
pre-tested questionnaire. Fasting blood samples were collected from all the
participants. Serum was
separated and stored at-80℃ till the time of
analysis. Lipids
were estimated using standard kits. Fatty acids in serum were estimated by Gas chromatography. The identified
Omega-3 fatty acid included were 18:3 (Alpha-linolenic acid), 20:5 (Eicosapentenoic acid) & 22:6
(Docosahexenoic acid). Among omega-6 included were 18:2 (linoleic acid), 18:3
(gamma-linolenic acid) & 20:4 (Arachidonic acid). Complete data was available for 176
participants (89% males and 11% females) with mean age of 47.23 ± 6.00 years. The bmi of the
participants was 24.88 ±3.43 Kg/m2 and waist circumference
was 91.50 ±9.56 cm.
The median of omega-6/omega-3 ratio in the study population was 36.69 (range:
6.21 -183.69). The levels of total cholesterol, triglycerides, ldl-cholesterol
and cholesterol/hdl ratio and apo B correlated significantly with omega-6/3 ratio. There was no correlation observed with hsCRP and LDL-particle size. A
direct relationship of omega-6/ omega-3 ratio with dyslipidemia was observed in our study.