Article citationsMore>>

Vannier, E., Miller, L.C. and Dinarello, C.A. (1992) Coordinated antiinflammatory effects of interleukin 4: Interleukin 4 suppresses interleukin 1 production but upregulates gene expression and synthesis of interleukin 1 receptor antagonist. Proceedings of the National Academy of Sciences of the United States of America, 89, 4076-4080. doi:10.1073/pnas.89.9.4076

has been cited by the following article:

• TITLE: Cytokine release in sepsis

  AUTHORS: Ian Burkovskiy, Joel Sardinha, Juan Zhou, Christian Lehmann

  KEYWORDS: Sepsis; Cytokine; Inflammation; Immunology

  JOURNAL NAME: Advances in Bioscience and Biotechnology, Vol.4 No.9, August 26, 2013

  ABSTRACT: Despite the advances in the therapeutic approaches, health care protocols and policies, sepsis continues to be an important problem in clinical medicine. High lethality of sepsis cases calls for a detailed and critically important study of the pathophysiology of sepsis. In this review, we discuss pathomechanisms of sepsis and the role of cytokines that are released in sepsis. We propose that the systemic levels of cytokines are not always reflecting the pathological picture and the immune status of the patient. One of the emerging approaches which may bring an effective treatment strategy exploits the endocannabinoid system for its immunomodulatory properties. Following from that, the research in this particular field is very important as it can bring understanding behind the complicated pathophysiology of sepsis.