TITLE:
A Novel Peptide from T-Cell Leukemia Translocation-Associated Gene (TCTA) Protein Inhibits Proliferation of a Small-Cell Lung Carcinoma
AUTHORS:
Shigeru Kotake, Toru Yago, Manabu Kawamoto, Yuki Nanke
KEYWORDS:
Osteoclast; Small-Cell Lung Carcinoma; TCTA
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.4 No.8A,
August
23,
2013
ABSTRACT: In 2009, we demonstrated that a
peptide, which we named “Peptide A”,
derived from the extracellular domain of T-cell leukemia
translocation-associated gene (TCTA) protein, inhibited both RANKL-induced
human osteoclastogenesis and pit formation of mature human osteoclasts. Here,
we examined the effect of
Peptide A on the cell proliferation of cell lines of small-cell lung carcinoma,
breast cancer, and prostate cancer: RERF-LC-MA, MCF-7, and PC-3, respectively.
Peptide A inhibited the proliferation of RERF-LC-MA, but not MCF-7 or PC-3.
TCTA protein was immunohistologically detected in RERF-LC-MA and MCF-7. Thus,
Peptide A may provide a novel strategy for the therapy of the patients with
small-cell lung carcinoma, especially with bone metastasis. In addition,
Peptide A may be useful for the treatment of various cancer patients with bone
metastasis.