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World Health Assembly Resolutions: 51.17, Emerging and Other Communicable Diseases: Antimicrobial Resistance; 58.27, Improving the Containment of Antimicrobial Resistance; 60.16, Progress in the Rational Use of Medicines, Including Better Medicines for Children.

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• TITLE: A controlled Intervention Study: Comparison of Intervention on the Antibiotic Prophylaxis of Three Clean Surgeries in Chinese Tertiary Hospitals

  AUTHORS: Yingdong Zheng, Ying Zhou, Ning Chen, Liang Zhou, Qing Yan

  KEYWORDS: Rational Antibiotic Use; Antibiotic Prophylaxis; Clean Surgeries; Thyroidectomy; Mastectomy; Hernia

  JOURNAL NAME: Pharmacology & Pharmacy, Vol.4 No.5, August 23, 2013

  ABSTRACT: A controlled intervention study was to promote rational antibiotic prophylaxis in clean surgeries in Chinese tertiary hospitals from 2008 to 2009. The effect of the intervention was measured and compared before and after intervention (intervention group, IG, including twelve hospitals), and compared with the control group (CG, including 164 tertiary hospitals distributed in 31 provinces). There were a total of 3961 and 657 cases identified in IG & CG for the study. Comparing the changes of IG with CG following the 3rd intervention, the proportion of antibiotics use without indication decreased from 61.9% (IG) & 84.4% (CG) (χ2 test, P χ2 test, P > 0.05); the rationality scores increased from 55.4 (IG) & 57.6 (CG) (t test, P > 0.05) to 77.0 (IG) & 64.3 (CG) (t test, P