TITLE:
Glycine supplementation reduces the severity of chemotherapy-induced oral mucositis in hamsters
AUTHORS:
Odara Maria de Sousa Sá, Nilza Nelly Fontana Lopes, Maria Teresa Seixas Alves, Rajesh V. Lalla, Maria Luiza Vilela Oliva, Eliana Maria Monteiro Caran
KEYWORDS:
Glycine; Chemotherapy; Oral Mucositis;Neutrophils; Malondialdehyde; Inflammatory
JOURNAL NAME:
Natural Science,
Vol.5 No.9,
August
23,
2013
ABSTRACT: Objective: Oral mucositis (OM) is a devastating toxicity associated with cytotoxic cancer therapy. The OM pathogenesis and the complex interactions occur in response to tissue insult. Application of this evolving model has aided in the development of mechanistically based therapies for the prevention and treatment of mucositis. The present study was to assess the effects of glycine supplementation on chemotherapy-induced oral mucositis. Methods: In a hamster cheek pouch model of chemotherapy-induced oral mucositis, one group of 20 animals received systemic glycine supplementation for 7 days, while another similar control group did not. Clinical mucositis severity and neutrophil infiltrate (on histology) were assessed by blinded examiners. Free radical production was measured as malondialdehyde (MDA) levels. Results: As compared to control animals, glycine-treated animals demonstrated a highly significant reduction in clinical severity of oral mucositis, neutrophil infiltrate, and MDA levels (p