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P. D. Jeffrey, “Structural Basis of Inhibition of CDK-Cyclin Complexes by INK4 Inhibitors,” Genes & Development, Vol. 14, No. 24, 2000, pp. 3115-3125. doi:10.1101/gad.851100

has been cited by the following article:

• TITLE: Evaluation of CDK6 and p16/INK4a-Derived Peptides Interaction

  AUTHORS: Andrey Kazennov, Andrey Alekseenko, Vladimir Bozhenko, Tatiana Kulinich, Nikolay Shuvalov, Yaroslav Kholodov

  KEYWORDS: Cyclin-Dependent Kinases; Molecular Dynamics; Umbrella Sampling; GPU; SASA

  JOURNAL NAME: Computational Molecular Bioscience, Vol.3 No.3, August 22, 2013

  ABSTRACT: The goal of this work is the development of novel peptides with high efficacy of inhibiting activity of CDK6/CyclinD complex. The peptides were derived from primary sequence of P16 protein and its homologues. The interactions between CDK6 and P16/INK4a-derived peptides are studied with molecular dynamics simulation employing umbrella sampling method. The SASA implicit solvent model was used for simulation, which was accelerated using NVIDIA GPUs.