TITLE:
Evaluation of Antioxidant and Cytotoxic Capacity of Croton bonplandianum. Baill
AUTHORS:
Muhammad Naeem Qaisar, Bashir Ahmad Chaudary, Muhammad Uzair, Sajid Nawaz Hussain
KEYWORDS:
Antioxidant Activity; Scavenging Activity; Cytotoxic Activity; Brine Shrimp; Croton bonplandianum
JOURNAL NAME:
American Journal of Plant Sciences,
Vol.4 No.9,
August
21,
2013
ABSTRACT: The
antioxidant and cytotoxic activities of Methanolic and Dichloromethane extracts
of Croton bonplandianum Baill were
evaluated in a bid to provide better scientific basis for the isolation of
bioactive compounds from the plant. The DPPH and hydroxyl radical scavenging
activities of the Methanolic extract were 59.62%, and Dichloromethane extract was not toxic. Gallic acid used as reference
compounds showed higher antioxidant activities to the plant extracts. Both methanolic and dichloromethane extracts
were evaluated for their brine shrimp lethality. Methanolic extract showed
cytotoxic activity in vitro with a LD50 value of 115.76
(0.0048-3.76) μg/ml. Etoposide was
used as standard drug. Put together, these results confirm that Croton bonplandianum extracts
possess appreciable natural antioxidant and cytotoxic potentials, thereby
providing good justification for the isolation of pure bioactive
compounds.