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Bellacosa, A., Kumar, C.C., Di Cristofano, A. and Testa, J.R. (2005) Activation of AKT kinases in cancer: Implications for therapeutic targeting. Advanced Cancer Research, 94, 29-86. doi:10.1016/S0065-230X(05)94002-5

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• TITLE: In vitro differentiation of human umbilical cord-derived mesenchymal stem cells into CD34+ cells via CD34 antibody

  AUTHORS: Shengnan Guo, Libin Guo, Maoxiang Sun, Wenyue Ma, Yujia Lu, Ying Liu

  KEYWORDS: Differentiation; Human Umbilical Cord-Derived Mesenchymal Stem Cells; CD34+ Cells

  JOURNAL NAME: Journal of Biomedical Science and Engineering, Vol.6 No.8A, August 20, 2013

  ABSTRACT: CD34+cells differentiated from mesenchymal stem cells (MSCs) have a strong biological function in cardiovascular regeneration. However, the molecular mechanisms of and the methods to improve the CD34+ cell differentiation from MSCs, especially from human MSCs (hUC-MSCs) are still unclear. In the current study, the effect of CD34 antibody on the CD34+ cell differentiation from human umbilical cord (UC)-derived MSCs (hUC-MSCs) is determined. The results have demonstrated that the expression of cd34 protein is significantly increased in hUC-MSCs treated with CD34 antibody. In addition, the cell proliferation is increased in hUC-MSCs after treatment with CD34 antibody. Moreover, the expression of PI3K, AKT, p-AKT proteins, which are signaling molecules related to stem cell differentiation, is increased by CD34 antibody. The results suggest that CD34 antibody could promote the differentiation of hUC-MSCs into CD34+ cells and PI3K/AKT may be involved in this important process.