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Jason, D.R., Rajendra, S.-M., Matthew, P.B., Steven, M.J., Lesley, D., Deepak, A.R., Tai, Y., Tamar, L.M., Ani, N., Brooks, U., Narutoshi, H., Toshiharu, S., Saltzman, W.M., Edward, S., Themis, R.K., Jordan, S.P., Christopher, K.B. (2010) Tissue-engineered vascular grafts transform into mature blood vessels via an inflammation-mediated process of vascular remodeling. Proceedings of the National Academy of Sciences of the USA, 107, 4669-4674.

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• TITLE: In vitro differentiation of human umbilical cord-derived mesenchymal stem cells into CD34+ cells via CD34 antibody

  AUTHORS: Shengnan Guo, Libin Guo, Maoxiang Sun, Wenyue Ma, Yujia Lu, Ying Liu

  KEYWORDS: Differentiation; Human Umbilical Cord-Derived Mesenchymal Stem Cells; CD34+ Cells

  JOURNAL NAME: Journal of Biomedical Science and Engineering, Vol.6 No.8A, August 20, 2013

  ABSTRACT: CD34+cells differentiated from mesenchymal stem cells (MSCs) have a strong biological function in cardiovascular regeneration. However, the molecular mechanisms of and the methods to improve the CD34+ cell differentiation from MSCs, especially from human MSCs (hUC-MSCs) are still unclear. In the current study, the effect of CD34 antibody on the CD34+ cell differentiation from human umbilical cord (UC)-derived MSCs (hUC-MSCs) is determined. The results have demonstrated that the expression of cd34 protein is significantly increased in hUC-MSCs treated with CD34 antibody. In addition, the cell proliferation is increased in hUC-MSCs after treatment with CD34 antibody. Moreover, the expression of PI3K, AKT, p-AKT proteins, which are signaling molecules related to stem cell differentiation, is increased by CD34 antibody. The results suggest that CD34 antibody could promote the differentiation of hUC-MSCs into CD34+ cells and PI3K/AKT may be involved in this important process.