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Israelson, A., Abu-Hamad, S., Zaid, H., Nahon, E. and Shoshan-Barmatz, V. (2007) Localization of the voltage-dependent anion channel-1 Ca2+-binding sites. Cell Calcium, 41(3), 235-244. doi:10.1016/j.ceca.2006.06.005

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• TITLE: Involvement of mitochondrial swelling in cytochrome c release from mitochondria treated with calcium and Alloxan

  AUTHORS: Takuya Ichimura, Mika Ito, Kiyoshi Takahashi, Kyohei Oyama, Koichi Sakurai

  KEYWORDS: Mitochondrial Swelling; Cytochrome C Release; Calcium; Alloxan; Mitochondrial Permeability Transition

  JOURNAL NAME: Journal of Biophysical Chemistry, Vol.2 No.1, February 22, 2011

  ABSTRACT: An early event in the induction of apoptosis is cytochrome c (Cyt c) release from mitochondria. We investigated the involvement of mitochonrial permeability transition (MPT) and mitochondrial swelling in Cyt c release from mitochondria treated with alloxan and/or calcium (Ca2+). When mitochondria were treated with a high concentration of Ca2+. alone or Ca2+. with alloxan (alloxan-Ca2+), the MPT was accompanied by mitochondrial swelling and the release of Cyt c. Cyclosporin A prevented the induction of MPT but only slightly decreased the release of Cyt c. High molecular weight polyethylene glycol almost completely inhibited MPT-dependent osmotic mitochondrial swelling and Cyt c release. However, MPT-independent mitochondrial swelling and Cyt c release induced by exogenous K+. were inhibited by the high molecular weight polyethylene glycol. Ruthenium red strongly decreased the amount of Cyt c released. These results suggest that mitochondrial swelling but not MPT is necessary for Cyt c release induced by Ca2+ alone or alloxan and Ca2+.