TITLE:
The Effects of Insulin Resistance and Inflammation on Renal Proximal Tubule Sodium Transport and Hypertension
AUTHORS:
Shoko Horita, Motonobu Nakamura, Masashi Suzuki, Hideomi Yamada, George Seki
KEYWORDS:
Insulin; Inflammation; TNF-α; Proximal Tubule; Insulin Resistance; PPARγ; Thiazolidinediones
JOURNAL NAME:
Open Journal of Endocrine and Metabolic Diseases,
Vol.3 No.5A,
August
19,
2013
ABSTRACT: Insulin resistance, closely linked to
inflammation, is recognized as a key factor in the onset and aggravation of
diabetes, cardio-renal syndrome, hypertension, and obesity. In the renal
proximal tubule, insulin resistance may increase renal sodium reabsorption,
leading to hypertension, edema and sometimes heart failure. Recently some
anti-diabetic agents have been shown to have effects on the transporters in
renal proximal tubule. Because renal proximal tubule mediates about 70% of
sodium reabsorption, it is quite important to clarify the function of renal
proximal tubule under insulin resistance and inflammation.