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Y. M. Zhang and C. O. Rock, “Evaluation of Epigallocatechin Gallate and Related Plant Polyphenols as Inhibitors of the FabG and FabI Reductases of Bacterial Type II Fatty-Acid Synthase,” Journal of Biological Chemistry, Vol. 279, No. 30, 2004, pp. 30994-31001. doi:10.1074/jbc.M403697200

has been cited by the following article:

• TITLE: Lipopolysaccharide-Deficient Mutants of Salmonella enterica Have Increased Sensitivity to Catechins

  AUTHORS: Miho Yoshii, Akira Okamoto, Michio Ohta

  KEYWORDS: Antimicrobial Activity; Catechins; Lipopolysaccharide; Gram-Negative Bacteria

  JOURNAL NAME: Advances in Microbiology, Vol.3 No.5, August 16, 2013

  ABSTRACT: Antimicrobial activity is one of the well-known biological characteristics of catechins, the main extract of green tea leaves. It is thought that catechins intercalate into the bacterial cell membrane and damage the lipid bilayer. However, the association between catechins and lipopolysaccharides, which consist of an O side chain, core oligosaccharide, and lipid A, has not been previously investigated. In this study, we evaluated the catechin sensitivity of Salmonella enterica mutants that lack the O side chain and have core oligosaccharides of different lengths. These rough mutants were more sensitive to catechins than a bacterial strain with intact lipopolysaccharide. We conclude that the O side chain and core oligosaccharide play an important role in protecting Gram-negative bacteria against the antimicrobial activity of catechins.