TITLE:
Compared Evaluation of Botulinum Toxin A and a Cosmetic Antiperspirant in the Treatment of Focal Axillary Hyperhidrosis
AUTHORS:
Meike Streker, Stefanie Lübberding, Martina Kerscher
KEYWORDS:
Hyperhidrosis; Aluminum Chloride; Botulinum Toxin; Antiperspirant; Sweating
JOURNAL NAME:
Journal of Cosmetics, Dermatological Sciences and Applications,
Vol.3 No.3,
August
15,
2013
ABSTRACT: Background: Primary focal
hyperhidrosis can significantly reduce quality of life. Therefore a lot of
treatment options in a range of conservative, physical and surgical techniques
are available. Objective: To assess the efficacy of an antiperspirant containing aluminum chloride
compared to a Botulinumtoxin A treatment for patients with primary focal hyperhidrosis. Methods and material: In this
randomized, single-center, half-side trail, a clinical score was done by patients and physician to
evaluate the severity of hyperhidrosis. Gravimetric tests were performed to
gather the amount of sweat per unit of time. Furthermore the efficacy was
determined using a four point questionnaire. Skin irritation was assessed by
measuring pH value and transepidermal water loss. Results: A total of 22 patients were
enrolled. Two weeks after baseline the hyperhidrosis level was significantly
reduced (BTX-A: ﹣92.9%,
AL: 66.7%). In addition
both treatment options induced a significant reduction of sweat production (BTX-A: ﹣80.8%, AL: 68.8%). Please change in: Patients
evaluated good resp, very good efficacy for both treatment options at day 28. pH value and TEWL
never left physiological
range. Conclusion: Both
botulinum toxin A treatment and an antiperspirant containing aluminum chloride
in the evaluated galenic formulation are an effective and safe treatment option
for axillary focal hyperhidrosis.