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Hodge, A.J. and Petruska, J.A. (1963) Recent studies with the electron microscope on ordered aggregates of the tropocollagen molecule. In: Ramachandran, G.N., Ed., Aspects of Protein Structure, Academic Press, New York, 289-300.

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• TITLE: Suprafibrillar structures of collagen, evidence for local organization and auxetic behaviour in architectures

  AUTHORS: Kate Patten, Tim Wess

  KEYWORDS: Collagen Structure; XRD (X-Ray Diffraction); Suprafibrillar; Organisation; Auxetic

  JOURNAL NAME: Journal of Biophysical Chemistry, Vol.4 No.3, August 9, 2013

  ABSTRACT: The suprafibrillar organisation of collagen rich tissues is the keystone to the diversity of resultant structures made from relatively similar materials. The local organisation between fibrils may be essential to suprafibril structures that are critical to functionality such as transparency in cornea, where specific lateral relationships between fibrils dictate optical properties. Here we show that corneal X-ray diffraction combined with mechanical strains to disrupt a specific suprafibrillar relationship between fibrils evidence and a coherent staggered axial relationship between collagen fibrils. The data also shows evidence for auxetic behavior of the collagen fibrils and reveals a 120 nm diffraction feature previously unreported in collagen tissues. The results show that suprafibrillar organisation can be an essential component in tissue architecture that has hitherto been ignored, but now must be considered in mechanical and structural models.