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Tanemura, H., Ishida, F., Miura, Y., Umeda, Y., Fukazawa, K., Suzuki, H., Sakaida, H., Matsushima, S., Shimosaka, S. and Taki, W. (2013) Changes in hemodynamics after placing intracranial stents. Neurologia Medico-Chirurgica, 53, 171-178. doi:10.2176/nmc.53.171

has been cited by the following article:

• TITLE: The effects of stent porosity on the endovascular treatment of intracranial aneurysms located near a bifurcation

  AUTHORS: Abraham Yik-Sau Tang, Hiu-Ning Chan, Anderson Chun-On Tsang, Gilberto Ka-Kit Leung, Kar-Ming Leung, Alfred Cheuk-Hang Yu, Kwok-Wing Chow

  KEYWORDS: Intracranial aneurysm; Endovascular Treatment; Stent; Stent Porosity; Computational Fluid Dynamics

  JOURNAL NAME: Journal of Biomedical Science and Engineering, Vol.6 No.8, August 8, 2013

  ABSTRACT: Intracranial aneurysm occurs when a cerebral artery develops an abnormal sac-like dilatation, and will cause massive bleeding in the subarachnoid space upon rupture. Endovascular stenting is a minimally invasive procedure in which a flow-diverting stent is deployed to cover the aneurysm neck, thereby restricting blood from entering the aneurysm and reducing the risk of rupture. The stent porosity, a crucial factor determining the intra-aneurysmal hemodynamics following treatment, is investigated by computational fluid dynamics techniques. Based on the computational results, a low porosity stent will dramatically reduce the flow velocity and the flow rate inside the side branch vessel. Conversely, a high porosity stent may not provide adequate flow reduction inside the aneurysm, possibly causing treatment failure. An advisable range of optimal stent porosity would be 60% to 75%, which can drastically reduce the flow rate into the aneurysm while preserving enough blood flow for the side branch vessel. Clinically, deployment of two or more flow-diverting stents may not increase treatment efficacy but can potentially lead to adverse effects due to side-branch hypoperfusion. The present quantitative analysis can also provide practical insight for future stent design.