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Boussel, L., Rayz, V., McCulloch, C., Martin, A., Acevedo-Bolton, G., Lawton, M., Higashida, R., Smith, W.S., Young, W.L. and Saloner, D. (2008) Aneurysm growth occurs at region of low wall shear stress: Patient-specific correlation of hemodynamics and growth in a longitudinal study. Stroke, 39, 2997-3002. doi:10.1161/STROKEAHA.108.521617

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• TITLE: The effects of stent porosity on the endovascular treatment of intracranial aneurysms located near a bifurcation

  AUTHORS: Abraham Yik-Sau Tang, Hiu-Ning Chan, Anderson Chun-On Tsang, Gilberto Ka-Kit Leung, Kar-Ming Leung, Alfred Cheuk-Hang Yu, Kwok-Wing Chow

  KEYWORDS: Intracranial aneurysm; Endovascular Treatment; Stent; Stent Porosity; Computational Fluid Dynamics

  JOURNAL NAME: Journal of Biomedical Science and Engineering, Vol.6 No.8, August 8, 2013

  ABSTRACT: Intracranial aneurysm occurs when a cerebral artery develops an abnormal sac-like dilatation, and will cause massive bleeding in the subarachnoid space upon rupture. Endovascular stenting is a minimally invasive procedure in which a flow-diverting stent is deployed to cover the aneurysm neck, thereby restricting blood from entering the aneurysm and reducing the risk of rupture. The stent porosity, a crucial factor determining the intra-aneurysmal hemodynamics following treatment, is investigated by computational fluid dynamics techniques. Based on the computational results, a low porosity stent will dramatically reduce the flow velocity and the flow rate inside the side branch vessel. Conversely, a high porosity stent may not provide adequate flow reduction inside the aneurysm, possibly causing treatment failure. An advisable range of optimal stent porosity would be 60% to 75%, which can drastically reduce the flow rate into the aneurysm while preserving enough blood flow for the side branch vessel. Clinically, deployment of two or more flow-diverting stents may not increase treatment efficacy but can potentially lead to adverse effects due to side-branch hypoperfusion. The present quantitative analysis can also provide practical insight for future stent design.