TITLE:
Necrotizing Scleritis Associated with 5-Fluorouracil and Sub-Tenon’s Block in Patient with Previous Trabeculectomy: A Case Report
AUTHORS:
Tuan A. Tran, Jeremy O’Connor, Xavier Fagan, Tu Tran, Dan Nguyen
KEYWORDS:
Necrotizing Scleritis; 5-Fluorouracil; Sub-Tenon’s Block; Glaucoma
JOURNAL NAME:
Open Journal of Ophthalmology,
Vol.3 No.3,
August
7,
2013
ABSTRACT: Necrotizing scleritis is the most
severe form of scleritis with a significant threat to vision and globe
integrity. It can be infectious, surgically induced necrotizing scleritis
(SINS) or systemic autoimmune associated. We report a case of necrotizing
scleritis associated with 5-fluorouracil (5-FU) at the site of sub tenon’s
block in a patient with previous trabeculectomy. To our knowledge, this is the first reported case of
necrotizing scleritis associated with 5-FU. This may implicate alternative
approaches to local anaesthetic techniques when using adjunctive 5-FU.