TITLE:
Heart Valve Lesions Due to the Formation of a Beta-Hemolytic Streptococ Role of Adhesion Molecules
AUTHORS:
Semsi Altaner, Turhan Kurum, Muzaffer Demir, Burhan Turgut, Turan Ege, Enver Duran
KEYWORDS:
Rheumatic Fever; Chronic Valve Disease; Cell Adhesion Molecules
JOURNAL NAME:
Surgical Science,
Vol.4 No.8,
July
25,
2013
ABSTRACT: Objectives: A rise in the levels of adhesion molecules such as VCAM-1, ICAM-1and
E-selectin in valve disease patients has been reported lately. In our study,
by detecting the presence of adhesion molecule expression in the valve endothelium
we will try to show the level of adhesion molecules in peripheral blood
leucocytes. Materials and Methods: Valve samples were obtained from patients having undergone aortic and mitral
valve replacement due to symptomatic aortic stenosis/aortic insufficiency
and/or mitral stenosis/mitral insufficiency. The clinical preoperative
diagnosis was made using two-dimensional echocardiography and Doppler
echocardiography. Rheumatic valves were in group B (n = 20).
Group A (n = 8) constituted the control group. Immunohistochemical staining was
performed using CD4, CD8, CD54/ICAM-1, and CD106/VCAM-1. Flow cytometric
analysis was performed. The Kolmogorov-Smirnov test and
Fisher’s exact test were used for the comparison of categorical variables. Results: Group A (non-rheumatic)
patients were found to be older than group B (rheumatic) patients (59.8 ± 11.4
years vs. 45.3 ± 11.8 years, p = 0.008). In group B VCAM-1 level was higher than
that of group A (296.6 ± 21.2 vs. 258.5 ± 42.1, p = 0.004).
CD11b monocyte in group B was higher than in group A (98.8 ± 0.5 vs.
92.9 ± 9.7, p = 0.003). CD11b granulocyte was higher in group B than in group A
(99.96 ± 0.05 vs. 93.79 ± 13.26, p = 0.33).
Significant differences were not determined in the other parameters. Conclusion: The fact that increases in
serum VCAM-1 and CD-11b only occurred in patients with rheumatic valvular disease
in our study suggests that inflammation in patients with the same hemodynamic
disorder is higher in rheumatic valvular disease than in the ones with non-rheumatic
valvular disease.