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Liu, J., Farmer, J.D., Lane, W.S., et al. (1991) Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell, 66, 807-815. doi:10.1016/0092-8674(91)90124-H

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• TITLE: Immunosuppressive therapy in pancreas and islet transplant: Need for simultaneous assessment of insulin sensitivity and secretion

  AUTHORS: Stefano Benedini, Andrea Caumo, leana Terruzzi, Livio Luzi

  KEYWORDS: Pancreas-Islets Transplantation; Insulin Sensitivity; Insulin Secretion; HOMA (The Homeostasis Model Assessment); QUICKI (The Quantitative Insulin-Sensitivity Check Index); Hyperinsulinemic Clamp

  JOURNAL NAME: Journal of Diabetes Mellitus, Vol.3 No.3, July 25, 2013

  ABSTRACT: Diabetes mellitus is a metabolic disease possible to treat via pancreas/islet transplantation but most immunosuppressive drugs are diabetogenic. In this letter, we review current up to date methods to assess insulin action and secretion (using the surrogate indexes) suggesting their use in large studies in populations of pancreas/ islets transplanted patients.