TITLE:
Immunosuppressive therapy in pancreas and islet transplant: Need for simultaneous assessment of insulin sensitivity and secretion
AUTHORS:
Stefano Benedini, Andrea Caumo, leana Terruzzi, Livio Luzi
KEYWORDS:
Pancreas-Islets Transplantation; Insulin Sensitivity; Insulin Secretion; HOMA (The Homeostasis Model Assessment); QUICKI (The Quantitative Insulin-Sensitivity Check Index); Hyperinsulinemic Clamp
JOURNAL NAME:
Journal of Diabetes Mellitus,
Vol.3 No.3,
July
25,
2013
ABSTRACT: Diabetes
mellitus is a metabolic disease possible to treat via pancreas/islet
transplantation but most immunosuppressive drugs are diabetogenic. In this
letter, we review current up to date methods to assess insulin action and
secretion (using the surrogate indexes) suggesting their use in large studies
in populations of pancreas/ islets transplanted patients.