TITLE:
The Effects of N-acetyl-seryl-aspartyl-lysyl-proline on Expression of NF-κb and MCP-1 in Rats with Silicosis
AUTHORS:
Qian Li, Fang Yang, Lijuan Zhang, Hong Xu, Wenli Zhang
KEYWORDS:
N-acetyl-seryl-aspartyl-lysyl-proline; Silicosis; Monocyte Chemotactic Protein-1; Nuclear Factor-κb
JOURNAL NAME:
International Journal of Clean Coal and Energy,
Vol.2 No.2B,
July
24,
2013
ABSTRACT: In the present study, we developed silicosis of
rat model by bronchial perfusion SiO2 dust, and intervenes with
AcSDKP, immunohisto chemistry was used to detect NF-κb and MCP-1 expression in lung
tissue, and positive cells were counted. We found that compared with silicotic
model group, the positive cells of NF-κb and MCP-1 were decreased significantly
in anti-fibrosis treatment of AcSDKP group. The findings suggest that AcSDKP could inhibit the expression of NF-κb
and MCP-1 in lung tissue of silicosos, this may be related to AcSDKP inhibit of
macrophage infiltration in lung tissue and reduced the degree of dust
alveolitis.