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Paneque, H.M., Lemos, C., Sousa, A., Velázquez, P.L., Fleming, M. and Sequeiros, J. (2009) Role of the disease in the psychological impact of pre-symptomatic testing for SCA2 and FAP ATTRV30M: Experience with the disease, kinship and gender of the transmitting parent. Journal of Genetic Counseling, 18, 483-493. doi:10.1007/s10897-009-9240-1

has been cited by the following article:

• TITLE: Anxiety and pre-symptomatic testing for neurodegenerative disorders

  AUTHORS: Lêdo Susana, Leite Ângela, Jorge Sequeiros

  KEYWORDS: Anxiety; Subscales; SAS; Psychological Impact; FAP; HD; MJD

  JOURNAL NAME: Open Journal of Genetics, Vol.3 No.2C, July 22, 2013

  ABSTRACT: In this retrospective study we have investigated the anxiety as an impact of pre-symptomatic testing (PST) for 3 autosomal dominant late-onset diseases: Huntington disease (HD), Machado-Joseph disease (MJD)and familial amyloidotic polyneuropathy (FAP)V30MTTR. The study included 686 subjects: 586 (85.4%) were the offspring at risk for FAP, 92 (13.4%) for HD and 8 (1.2%) to MJD. Of these, 352 received the carrier result and 305 the non-carrier result. As indicator of anxiety distress was taken the Self-Rating Anxiety Scale of Zung (SAS), applied in the pre-test and the three post-test moments: three weeks, 6 months and one year after notification of test results. Values decreased significantly along the four evaluation moments, regardless the studied disease or test result. For female population, SAS means cores revealed results of clinical anxiety at pre-test, only decreasing to non clinical scores a year after PST disclosure.