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Lonn, E., Yusuf, S., Arnold, M.J., Sheridan, P., Pogue, J., Micks, M., et al. (2006) Homocysteine lowering with folic acid and B vitamins in vascular disease. The New England Journal of Medicine, 354, 1567-1577. doi:10.1056/NEJMoa060900

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• TITLE: Addition of Metanx in pregabalin partial responders for painful diabetic neuropathy

  AUTHORS: Allen Mark Jacobs, Dunlei Cheng

  KEYWORDS: L-Methylfolate; Methylcobalamin; Metanx; Diabetic Neuropathy

  JOURNAL NAME: Journal of Diabetes Mellitus, Vol.3 No.3, July 22, 2013

  ABSTRACT: Objective: To study the effect of addition of Metanxon burning parasthesias in patients with symptomatic diabetic neuropathy who had obtained only partial symptom resolution with pregabalin. Research design and methods: This was an open-label pilot study. There were 16 patients (7 males, 9 females) in the study group and 8 patients (3 males, 5 females) in the control group. A patient numeric rating scale (0 - 10) of neuropathy associated pain was obtained at baseline and at 20 weeks. The control group continued on a fixed dosage of pregabalin (Lyrica) without additional medication, while the study group was supplemented with Metanx(L-methylfolate, methylcobalamin, and pyridoxal 5- phosphate), in addition to being continued on a fixed dosage of pregabalin. Results: After 20 weeks, patients in the study group experienced greater pain relief compared to the control group, (87.5% vs. 25% respectively, p = 0.005). The average pain score reduction after 20 weeks in the study group was 3 compared to0.25 inthe control group (p may be used for the relief of pain in patients that have obtained only partial resolution of symptomatology from pregabalin.