TITLE:
Addition of Metanx in pregabalin partial responders for painful diabetic neuropathy
AUTHORS:
Allen Mark Jacobs, Dunlei Cheng
KEYWORDS:
L-Methylfolate; Methylcobalamin; Metanx; Diabetic Neuropathy
JOURNAL NAME:
Journal of Diabetes Mellitus,
Vol.3 No.3,
July
22,
2013
ABSTRACT: Objective: To study the effect of addition of Metanxon burning parasthesias in patients with symptomatic diabetic neuropathy who
had obtained only partial symptom resolution with pregabalin. Research design
and methods: This was an open-label pilot study. There were 16 patients (7
males, 9 females) in the study group and 8 patients (3 males, 5 females) in the
control group. A patient numeric rating scale (0 - 10) of neuropathy
associated pain was obtained at baseline and
at 20 weeks. The control group continued on a fixed dosage of
pregabalin (Lyrica) without additional medication, while the study
group was supplemented with Metanx(L-methylfolate,
methylcobalamin, and pyridoxal 5- phosphate), in addition to being continued on
a fixed dosage of pregabalin. Results: After 20 weeks, patients in the study group
experienced greater pain relief compared to the control group, (87.5% vs. 25%
respectively, p = 0.005). The average pain score reduction after 20 weeks in
the study group was 3 compared to0.25
inthe control group (p may be used for the relief of pain in
patients that have obtained only partial resolution of symptomatology from
pregabalin.