TITLE:
Sentinel-Node-Driven Personalized Radiation Techniques Ranging from Partial Breast Irradiation to Regional Nodal Radiation after Breast-Conserving Surgery
AUTHORS:
Kazuhiko Sato, Yoshio Mizuno, Hiromi Fuchikami, Masahiro Kato, Takahiro Shimo, Jun Kubota, Naoko Takeda, Yuko Inoue, Hiroshi Seto, Tomohiko Okawa
KEYWORDS:
Breast Cancer; Personalized Radiotherapy; Sentinel Node; Partial Breast Irradiation; Regional Nodal Radition
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.4 No.7A,
July
22,
2013
ABSTRACT: Background: Breast-conserving
surgery (BCS) followed by whole breast irradiation (WBI) has become the standard
of care for treating patients with early-stage breast cancer. Recently, various
radiation techniques followed by BCS have been reported. We have been investigating
“personalized radiotherapy after BCS” ranging from accelerated partial breast
irradiation (APBI) to WBI with regional nodal irradiation (RNI) based on the
axillary node status. In this study, we compared different cohorts that
received personalized radiotherapy. Method: Of 317 consecutive patients who underwent BCS followed by radiotherapy since November 2007, 187 who
received APBI and 122 who received WBI were analyzed. Results: The local-only recurrence rate was 1.1% in the APBI group
and 3.3% in the WBI group, and the regional-only recurrence rate was 1.1% for
APBI and 0.8% for WBI. Conclusions: The clinical efficacy of APBI for local control after BCS was comparable to
that of WBI ± RNI. Although this study was based on a small number of patients
with a short follow-up period, the feasibility of breast-conserving therapy
using multicatheter brachytherapy to achieve acceptable clinical outcomes was
demonstrated.