TITLE:
Clinico-radiological dissociation in multiple sclerosis: Future prospects
AUTHORS:
Elena Zapata-Arriaza, María Díaz-Sánchez
KEYWORDS:
Multiple Sclerosis; Disability Progression; Magnetic Resonance Imaging; Diffusion-Tensor Imaging, Proton Magnetic Resonance Spectroscopic Imaging
JOURNAL NAME:
World Journal of Neuroscience,
Vol.3 No.3,
July
19,
2013
ABSTRACT: Magnetic resonance imaging (MRI) has significantly
contributed to our capabilities of diagnosis multiple sclerosis (MS) since it
is able to detect demyelinating lesions in
almost 100% of patients. However, there are modest correlations between
irreversible disability and white matter lesion load, as measured by
T2-weighted MRI scans, which represents the clinicoradiological paradox of MS. We
report the case of a patient with MS and few neurological manifestations
despite extensive T2 visible morphologic abnormalities. The use of
non-conventional MRI techniques, which are more specific in the analysis of the
pathological substrate of demyelinating lesions and normal appearing brain
matter (both white and gray matter), might assist us to overcome this
limitation of conventional MRI.