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Barros, L.F., Yudilevich, D.L., Jarvis, S.M., Beaumont, N. and Baldwin, S.A. (1995) Quantitation and immunolocalization of glucose transporters in the human placenta. Placenta, 16, 623-633. doi:10.1016/0143-4004(95)90031-4

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• TITLE: Glucose transporters expression in the placental terminal villi of preeclampsia and intrauterine growth retardation complicated pregnancies

  AUTHORS: Elena A. Dubova, Konstantin A. Pavlov, Galina V. Kulikova, Alexander I. Shchegolev, Gennady T. Sukhikh

  KEYWORDS: Preeclampsia; Placenta; GLUT-1; GLUT-3

  JOURNAL NAME: Health, Vol.5 No.7D, July 18, 2013

  ABSTRACT: Introduction: Transmembrane sodium-independent glucose transporters (GLUTs) play an important role in both placental and fetal development by the providing transplacental glucose transport. Abnormal GLUT-1 and GLUT-3 placental expression could play a role in such late pregnancy complications development as preeclampsia and intrauterine growth retardation. Materials and Methods: Immunohistochemistry was performed to reveal patterns of GLUT-1 and GLUT-3 expression in the placental terminal villi compartments. Results: GLUT-1 syncytial expression in the terminal villi of severe PE cases (both with and without IUGR) was significantly lower in compare to control group. We also report about GLUT-3 both syncytial and endothelial expression in the near term and term placental terminal villi without significant difference between the study and control groups. Conclusion: other study should be performed to establish the nature of GLUT-1 downregulation in severe preeclampsia cases and whether GLUT-3 is expressed in the syncytiotrophoblast of near term and term placentas or not.