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Hauguel-De Mouzon, S., Challier, J., Kacemi, A., Cauzac, M., Malek, A. and Girard, J. (1997) The GLUT3 glucose transporter isoform is differentially expressed within human placental cell types. The Journal of Clinical Endocrinology & Metabolism, 82, 2689-2694. doi:10.1210/jc.82.8.2689

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• TITLE: Glucose transporters expression in the placental terminal villi of preeclampsia and intrauterine growth retardation complicated pregnancies

  AUTHORS: Elena A. Dubova, Konstantin A. Pavlov, Galina V. Kulikova, Alexander I. Shchegolev, Gennady T. Sukhikh

  KEYWORDS: Preeclampsia; Placenta; GLUT-1; GLUT-3

  JOURNAL NAME: Health, Vol.5 No.7D, July 18, 2013

  ABSTRACT: Introduction: Transmembrane sodium-independent glucose transporters (GLUTs) play an important role in both placental and fetal development by the providing transplacental glucose transport. Abnormal GLUT-1 and GLUT-3 placental expression could play a role in such late pregnancy complications development as preeclampsia and intrauterine growth retardation. Materials and Methods: Immunohistochemistry was performed to reveal patterns of GLUT-1 and GLUT-3 expression in the placental terminal villi compartments. Results: GLUT-1 syncytial expression in the terminal villi of severe PE cases (both with and without IUGR) was significantly lower in compare to control group. We also report about GLUT-3 both syncytial and endothelial expression in the near term and term placental terminal villi without significant difference between the study and control groups. Conclusion: other study should be performed to establish the nature of GLUT-1 downregulation in severe preeclampsia cases and whether GLUT-3 is expressed in the syncytiotrophoblast of near term and term placentas or not.