TITLE:
The antihyperglycemic effect of Bridelia ndellensis ethanol extract and its fractions is mediated by an insulinotropic action
AUTHORS:
Selestin Dongmo Sokeng, Begum Rokeya, Jamadder Mohammed Abdul Hannan, Liaquat Ali, Pierre Kamtchouing
KEYWORDS:
Bridelia ndellensis; Ethanol Extract; Intestinal Glucose Absorption; Insulin Secretion in Vitro
JOURNAL NAME:
Journal of Diabetes Mellitus,
Vol.3 No.3,
July
17,
2013
ABSTRACT:
Backgroung: Bridelia ndellensis (Euphorbiaceae) is used as a traditional plant treatment of diabetes. The aim
of the present study was to investigate the mechanism involved in the antihyperglycemic
effects of this plant. Methods: An intestinal perfusion technique was used to
study the effect of the ethanol extract of B. ndellensis on the
intestinal absorption of glucose in normal rats fasted for 36 h. The effect of
the extract (50 and 100 mg/kg) on Insulin secretion was evaluated using
BRIN-BD11 pancreatic cells. Results: In a perfused rat intestinal preparation in situ, the plant extract at a
concentration of 5 mg/ml did not show any inhibitory effects on glucose
absorption when compared with control animals. Ouabain which is an inhibitor of
glucose transport across the small intestine significantly (p Barium sulphate milk
in rats. The ethanol extract of B.
ndellensis at concentrations of 50 and100mg/ml
stimulated in a concentration-dependent manner the insulin secretion from
BRIN-BD11 cells in vitro. The
induction of insulin release was significantly different when compared to
control with the concentration of 100 μg/ml (P B.
ndellensis ethanol extract stimulates insulin secretion and does not affect
the glucose absorption, and it has suggested that the antihyperglycemic effects
of B. ndellensis is partly mediated
by the stimulation of insulin secretion.