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S. Segawa, Y. Nakakita, Y. Takata, Y. Wakita, T. Kaneko, H. Kaneda, J. Watari and H. Yasui, “Effect of Oral Ad ministration of Heat-Killed Lactobacillus brevis SBC 8803 on Total and Ovalbumin-Specific Immunoglobulin E Production through the Improvement of Th1/Th2 Bal ance,” International Journal of Food Microbiology, Vol. 121, No. 1, 2008, pp. 1-10. doi:10.1016/j.ijfoodmicro.2007.10.004

has been cited by the following article:

• TITLE: Heat-Killed Lactobacillus brevis SBC8803 Induces Serotonin Release from Intestinal Cells

  AUTHORS: Yasukazu Nakaita, Hirotaka Kaneda, Tatsuro Shigyo

  KEYWORDS: Serotonin; Lactobacillus Brevis; Mice; Intestinal Cells; 5-HT3 Receptors

  JOURNAL NAME: Food and Nutrition Sciences, Vol.4 No.8, July 17, 2013

  ABSTRACT: Previously, we reported that changes induced in autonomic neurotransmission in rats by Lactobacillus brevis SBC8803 may be mediated by serotonin 3 (5-HT3) receptors. In this study, we evaluated the effects of heat-killed L. brevis SBC8803 on serotonin (5-HT) releasing from intestinal cells. In the in vitro study, L. brevis SBC8803 stimulated 5-HT release from cultured rat endocrine RIN-14B cells (SBC8803 vs. sterile water; P in vivo study, 2 mg of heat-killed L. brevis SBC8803 was administered using a stomach sonde (feeding needle) to C57BL/6J mice. Analysis of plasma by ELISA showed gradually increase in 5-HT concentrations (0 min vs. 60 min; P ex vivo cultured intestinal loops composed of duodenum and part of the jejunum, from C3H/HeN and C57BL/6J male mice indicated that L. brevis SBC8803 effectively induced 5-HT release (SBC8803 vs. sterile water; P L. brevis SBC8803 may stimulate 5-HT release from mouse intestinal cells such as enterochromaffin cells.