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Naughton, B.A., Dornfest, B.S., Bush, M.E., Carlson, C.A. and Lapin, D.M. (1990) Immune activation is associated with phenylhydrazine-induced anemia in the rat. Journal of Laboratory and Clinical Medicine, 116, 498-507.

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• TITLE: An antibody present in everybody that attacks malaria infected erythrocytes

  AUTHORS: James Kennedy

  KEYWORDS: Band 3; Malaria; Sickle

  JOURNAL NAME: Journal of Biomedical Science and Engineering, Vol.6 No.7A, July 17, 2013

  ABSTRACT: These malaria targeting antibodies are band 3 antibodies and they recognize a special configuration of a molecule called band 3 that is present on erythrocytes. The special band 3 configuration is present on the surface of senescent erythrocytes, malaria infected erythrocytes, the erythrocytes of certain hemoglobinnopathies such as sickle cell disease and on the erythrocytes of some metabolic disorders such as G6PD. Note that these hemoglobinopathies and metabolic disorders all aid in the survival of falciparum malaria to such an extent that their incidence is increased in falciparum endemic areas [1-3]. Though there are many adhesive molecules involved in the pathology of falciparum malaria and sickle cell anemia, the focus here is on the band 3 molecules.