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E. Morey-Holton, R. K. Globus, A. Kaplansky and G. Durnova, “The Hindlimb Unloading Rat Model: Litera ture Overview, Technique Update and Comparison with Space Flight Data,” Advances in Space Biology and Me dicine, Vol. 10, 2005, pp. 7-40.

has been cited by the following article:

• TITLE: Mathematical Modeling of Cardiomyocytes’ and Skeletal Muscle Fibers’ Membrane: Interaction with External Mechanical Field

  AUTHORS: Irina V. Ogneva, Nikolay S. Biryukov

  KEYWORDS: Mathematical Modeling in Biology; Muscle Cell; Cell Mechanosensitivity; Microgravity

  JOURNAL NAME: Applied Mathematics, Vol.4 No.8A, July 16, 2013

  ABSTRACT: We propose a mathematic model of muscle cell membrane based on thin-walled elastic rod theory. A deformation occurs in rodents’ skeletal and cardiac cells during a period of antiorthostatic suspension. We carried out a quantitative evaluation of the deformation using this model. The calculations showed the deformation in cardiac cells to be greater than in skeletal ones. This data corresponds to experimental results of cell response that appears intense in cardiomyocytes than in skeletal muscle cells. Moreover, the deformation in skeletal and heart muscle cells has a different direction (stretching vs. compression), corresponding to experimental data of different adaptive response generation pathways in cells because of external mechanical condition changes.