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Nguyen, A.D., Nguyen, T.A., Cenik, B., Yu, G., Herz, J., Walther, T.C., et al. (2013) Secreted progranulin is a homodimer and is not a component of high-density lipoproteins (HDL). Journal Biological Chemistry, 288, 8627-8635. doi:10.1074/jbc.M112.441949

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• TITLE: Intravascular infusion of autologous delipidated plasma induces antiatherogenic lipoproteins and causes regression of atherosclerosis —Studies in non-primates, monkeys and humans

  AUTHORS: Bill E. Cham, Tania R. Chase

  KEYWORDS: Atherosclerosis; Delipidation; Regression; Pre-β HDL; Delipidated LDL

  JOURNAL NAME: Health, Vol.5 No.7A, July 16, 2013

  ABSTRACT: Atherosclerosis is the primary pathophysiological cause of heart disease and cerebrovascular disease. It is responsible for more than 20% of deaths worldwide each year. Treatments for atherosclerosis may include lifestyle changes, drugs, and medical procedures or surgery. There is a need for a rapid and effective treatment for this disease. In 1976, it was hypothesized that a multifunctional plasma delipidation process when applied to hyperlipidemic patients would lead to rapid regression of atherosclerosis. The procedure has now been applied to a variety of non-primates, primates and humans. In all models studied, large quantities of antiatherogenic lipoprotein particles were generated that led to the mechanisms of reverse cholesterol transport. Trends to regression and actual regression of atherosclerosis have now been reported using a specific plasma delipidation process consisting of lipid extraction from plasma with mixtures of butanol and ethers.