TITLE:
Intravascular infusion of autologous delipidated plasma induces antiatherogenic lipoproteins and causes regression of atherosclerosis —Studies in non-primates, monkeys and humans
AUTHORS:
Bill E. Cham, Tania R. Chase
KEYWORDS:
Atherosclerosis; Delipidation; Regression; Pre-β HDL; Delipidated LDL
JOURNAL NAME:
Health,
Vol.5 No.7A,
July
16,
2013
ABSTRACT: Atherosclerosis is
the primary pathophysiological cause of
heart disease and cerebrovascular disease. It is responsible for more
than 20% of deaths worldwide each year. Treatments for atherosclerosis may
include lifestyle changes, drugs, and
medical procedures or surgery. There is a need for a rapid and effective
treatment for this disease. In 1976, it was hypothesized that a multifunctional plasma delipidation process when applied to hyperlipidemic patients would lead to rapid regression of
atherosclerosis. The procedure has now been applied
to a variety of non-primates, primates and humans. In all models studied,
large quantities of antiatherogenic lipoprotein particles were generated that
led to the mechanisms of reverse cholesterol transport. Trends to regression
and actual regression of atherosclerosis have now been reported using a specific plasma
delipidation process consisting of lipid extraction from plasma with mixtures
of butanol and ethers.