TITLE:
Thermal Decomposition of Some Cardiovascular Drugs (Telmisartane, Cilazapril and Terazosin HCL)
AUTHORS:
L. M. Al-Harbi, E. H. El-Mossalamy, A. Y. Obaid, M. A. EL-RIES
KEYWORDS:
Anti-Hypertensive Drugs; Quality Control; Thermal Analysis; Thermogravimetry; Derivative Thermogravimetry; Differential Thermal Analysis
JOURNAL NAME:
American Journal of Analytical Chemistry,
Vol.4 No.7,
July
15,
2013
ABSTRACT: Thermal analysis of some antihypertensive drugs,
Telmisartan, Cilazapril and Terazosin HCL was achieved. Thermogravimetry,
derivative thermogravimetry and differential thermal analysis were used through
the work. Thermogravimetric parameters such as activation energy, frequency
factor and reaction order were calculated. The results show the stability value
decrease in the order Telmisartan > Cilazapril > Terazosin. This
method can be used in the quality control of pharmaceutical compounds because it is simple, fast and cheap.