TITLE:
Effects of a New Human Recombinant MnSOD in the Treatment of Photoaging and Actinic Keratosis
AUTHORS:
Maria Grazia Ruggiero, Maria Laura Pollio, Antonietta Schiattarella, Antonella Borrelli, Aldo Mancini, Alessandra Pica, Patrizia Forgione
KEYWORDS:
Photoaging; Actinic Keratosis; MnSOD; Skin Cancer Lesions
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.4 No.6A,
July
15,
2013
ABSTRACT: Physiological processes, as aerobic metabolism and inflammatory response, generate reactive oxygen species (ROS) that may induce cellular injury when their amount is increased and antioxidant defense mechanisms are overwhelmed. Also, ROS are generated following UV skin irradiation able to deplete the natural antioxidant defenses in the skin. The increase in exposure to UV may lead to photoaging and precancerous skin lesions (actinic keratosis). New antioxidant strategies in the prevention and therapy of skin lesions are urgently needed. In this study, we evaluated the antioxidant efficacy of a recombinant form of human manganese superoxide dismutase able to inhibit reactive oxygen species production in some patients affected by severe photoaging and actinic keratosis.