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Syv?lahti, E.K., Kunelius, R. and Laurén, L. (1988) Effects of antiparkinsonian drugs on muscarinic receptor binding in rat brain, heart and lung. Pharmacology & Toxicology, 62, 90-94.

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• TITLE: Some worlds about postmortem blood atropine concentrations

  AUTHORS: Phak-Rop Pos Pok

  KEYWORDS: Atropine; Postmortem Redistribution

  JOURNAL NAME: Forensic Medicine and Anatomy Research, Vol.1 No.3, July 11, 2013

  ABSTRACT: Atropine is an anticholinergic drug, used in treatment of spasm and pain. Postmortem blood atropine concentrations tend to be regionally dependent. We reported in this work the analytical findings of atropine in the peripheral and heart blood from a case of suspected death. Atropine wasdetermined in both peripheral and heart blood by liquid chromatography with tandem mass spectrometry. Towards the reference ranges, the concentration of atropine in the peripheral blood is therapeutic, and in the heart blood is lethal. The high concentration of atropine in the heart blood reflects postmortem redistribution rather than cardiotoxicity. The findings have great implications for forensic toxicology.