Article citationsMore>>

J. R. S. Hoult and M. Paydt, “Pharmacological and Biochemical Actions of Simple Coumarins: Natural Products with Therapeutic Potential,” General Pharmacology, Vol. 27, No. 4, 1996, pp. 713-722. doi:10.1016/0306-3623(95)02112-4

has been cited by the following article:

• TITLE: Process for the Obtention of Coumaric Acid from Coumarin: Analysis of the Reaction Conditions

  AUTHORS: Néstor N. López-Castillo, Alma D. Rojas-Rodríguez, Brenda M. Porta, M. Javier Cruz-Gómez

  KEYWORDS: Coumarin; Coumaric Acid; Ester Hydrolysis

  JOURNAL NAME: Advances in Chemical Engineering and Science, Vol.3 No.3, July 11, 2013

  ABSTRACT: Coumaric acid can be obtained from basic hydrolysis of coumarin, through a reaction process consisting on opening the lactone ring and cis-trans isomerization. Parameters such as reaction time, temperature, NaOH concentration, solvent and reaction atmosphere, have been thoroughly studied and analyzed, in order to determine the appropriate conditions for the maximum conversion efficiency of coumarin into coumaric acid. Experimental results show that the best conditions are a 1 hour reaction time, at 160℃, with a 20% sodium hydroxide aqueous solution, and in an inert reaction atmosphere.