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Knochenhauer, E.S., Key, T.J., Kahsar-Miller, M., Waggoner, W., Boots, L.R. and Azziz, R. (1998) Prevalence of the polycystic ovary syndrome in unselected black and white women of the southeastern United States: A prospective study. The Journal of Clinical Endocrinology & Metabolism, 83, 3078-3082. doi:10.1210/jc.83.9.3078

has been cited by the following article:

• TITLE: Randomized controlled trial of Letrozole versus Clomiphene citrate for induction of ovulation in polycystic ovarian syndrome (PCOS): A Malaysian experience

  AUTHORS: Nik Hazlina Nik Hussain, Munawwirah Ismail, Murizah Mohd. Zain, Pu Chan Yeu, Roszaman Ramli, Wan Mohd Zahiruddin Wan Mohammad

  KEYWORDS: Polycystic Ovarian Syndrome; Ovulation Induction; Clomiphene Citrate; Letrozole

  JOURNAL NAME: Open Journal of Obstetrics and Gynecology, Vol.3 No.5B, July 9, 2013

  ABSTRACT: Background: The purpose of this study was to compare the effectiveness of Letrozole versus Clomiphene citrate for ovulation induction in polycystic ovarian syndrome (PCOS) with infertility. Methods: This was a prospective randomized trial involving 150 women with PCOS attending the Infertility Clinic at three hospitals in Malaysia. During the initial visit, anthropometric measurements and baseline investigations were performed. Patients were randomized to 5.0 mg Letrozole daily (75 patients) or 100 mg Clomiphene citrate daily (75 patients) from the fifth until the ninth day of menstruation. Serial transvaginal scans were performed to see the dominant follicles, endometrial thickness and number of follicles. Transvaginal scans were performed serially to look for evidence of ovulation. Results: The subjects were homogenously distributed. The difference between Letrozole and Clomiphene citrate for ovulation rate was 59 (78.7%) versus 40 (53.3%). Patients taking Letrozole exhibited a mean endometrial thickness (ET) at mid cycle of menses (Day 11-D14) of9.2 mm(SD ± 2.3) versus8.4 mm(SD ± 2.2) for patients taking Clomiphene citrate, and these differences were statistically significant (p