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Nagado, T., Arimura, K., Sonoda, Y., Kurono, A., Horikiri, Y., Kameyama, A., et al. (1999) Potassium current suppression in patients with peripheral nerve hyperexcitability. Brain, 122, 2057-2066. doi:10.1093/brain/122.11.2057

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• TITLE: Oxaliplatin induced hyperexcitability syndrome in patient with appendiceal adenocarcinoma

  AUTHORS: Nicola Jabbour, Maher Alchreiki, Mohammad Hussain

  KEYWORDS: Oxaliplatin; Peripheral Neuropathy; Neuromyotonia; Hyperexcitability Syndrome; Appendiceal Adenocarcinoma; Sodium Channels

  JOURNAL NAME: Case Reports in Clinical Medicine, Vol.2 No.4, July 8, 2013

  ABSTRACT: Oxaliplatin is a novel platinum compound with clinical activity against several solid tumors. It has been associated with sensory neuropathies and, rarely, a neuromyotonia-like hyperexcitability syndrome; a form of peripheral neuropathy manifested by tremor and twitching activity of muscles. We present a case of hyperexcitability syndrome developed during the treatment of stage III appendiceal adenocarcinoma with oxaliplatin-containing regimen and was successfully treated with Pregabalin.