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Hart, I.K., Waters, C., Vincent, A., Newland, C., Beeson, D., Pongs, O., et al. (1997) Autoantibodies detected to expressed K+ channels are implicated in neuromyotonia. Annals of Neurology, 41, 238-246.

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• TITLE: Oxaliplatin induced hyperexcitability syndrome in patient with appendiceal adenocarcinoma

  AUTHORS: Nicola Jabbour, Maher Alchreiki, Mohammad Hussain

  KEYWORDS: Oxaliplatin; Peripheral Neuropathy; Neuromyotonia; Hyperexcitability Syndrome; Appendiceal Adenocarcinoma; Sodium Channels

  JOURNAL NAME: Case Reports in Clinical Medicine, Vol.2 No.4, July 8, 2013

  ABSTRACT: Oxaliplatin is a novel platinum compound with clinical activity against several solid tumors. It has been associated with sensory neuropathies and, rarely, a neuromyotonia-like hyperexcitability syndrome; a form of peripheral neuropathy manifested by tremor and twitching activity of muscles. We present a case of hyperexcitability syndrome developed during the treatment of stage III appendiceal adenocarcinoma with oxaliplatin-containing regimen and was successfully treated with Pregabalin.