TITLE:
Oxaliplatin induced hyperexcitability syndrome in patient with appendiceal adenocarcinoma
AUTHORS:
Nicola Jabbour, Maher Alchreiki, Mohammad Hussain
KEYWORDS:
Oxaliplatin; Peripheral Neuropathy; Neuromyotonia; Hyperexcitability Syndrome; Appendiceal Adenocarcinoma; Sodium Channels
JOURNAL NAME:
Case Reports in Clinical Medicine,
Vol.2 No.4,
July
8,
2013
ABSTRACT: Oxaliplatin is a
novel platinum compound with clinical activity against several solid tumors. It
has been associated with sensory neuropathies and, rarely, a neuromyotonia-like
hyperexcitability syndrome; a form of peripheral neuropathy manifested by
tremor and twitching activity of muscles. We present a case of
hyperexcitability syndrome developed during the treatment of stage III appendiceal adenocarcinoma with oxaliplatin-containing regimen and was successfully treated with Pregabalin.