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Institute of Medicine, “Dietary Reference Intakes for Energy, Carbohydrates, Fibers, Fats, Fatty Acids, Cholesterol, Protein and Aminoacids,” pp. 7-8.

has been cited by the following article:

• TITLE: Acute Toxicity and Genotoxic Evaluation of Metlin® and Metlos® (Organic Agave Fructans)

  AUTHORS: M. I. Gracia, M. M. Tinoco, H. M. Rivera, B. F. Sanchez, P. G. Tapia, L. M. Altamirano, R. L. Romero, O. L. García

  KEYWORDS: Agave Fructans; Inulin; Fructooligosacharides

  JOURNAL NAME: Food and Nutrition Sciences, Vol.4 No.7A, July 5, 2013

  ABSTRACT: The aim of the study was to contribute to the information on agave soluble fibers since research has been focused on chicory fiber but not in agave products; thus we assess the acute toxicity and genotoxicity of two organic and high purity dietary soluble fibers from agave, Metlin? and Metlos?. We performed an acute toxicity assay in Hsd:ICR mice and Hsd:Wistar rats and an in vivo genotoxic test. Results showed that there are no deaths at any doses or genotoxicity, so it can be concluded that these products are non-toxic, at the administrated doses and none showed a cytotoxic, clastogenic or aneuploidic effect.