TITLE:
Acute Toxicity and Genotoxic Evaluation of Metlin® and Metlos® (Organic Agave Fructans)
AUTHORS:
M. I. Gracia, M. M. Tinoco, H. M. Rivera, B. F. Sanchez, P. G. Tapia, L. M. Altamirano, R. L. Romero, O. L. García
KEYWORDS:
Agave Fructans; Inulin; Fructooligosacharides
JOURNAL NAME:
Food and Nutrition Sciences,
Vol.4 No.7A,
July
5,
2013
ABSTRACT: The aim of the study was to contribute to the information on agave soluble fibers since research has been focused on chicory fiber but not in agave products; thus we assess the acute toxicity and genotoxicity of two organic and high purity dietary soluble fibers from agave, Metlin? and Metlos?. We performed an acute toxicity assay in Hsd:ICR mice and Hsd:Wistar rats and an in vivo genotoxic test. Results showed that there are no deaths at any doses or genotoxicity, so it can be concluded that these products are non-toxic, at the administrated doses and none showed a cytotoxic, clastogenic or aneuploidic effect.