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P. Froguel, H. Zouali, N. Vionnet, G. Velho, M. Vaxillaire, F. Sun, S. Lesage, M. Stoffel, J. Takeda, P. Passa, et al., “Familial Hyperglycemia Due to Mutations in Glucokinase—Definition of a Subtype of Diabetes Mellitus,” The New England Journal of Medicine, Vol. 328, 1993, pp. 697-702. doi:10.1056/NEJM199303113281005

has been cited by the following article:

• TITLE: Persian Shallot (Allium hirtifolium Boiss) Extract Elevates Glucokinase (GCK) Activity and Gene Expression in Diabetic Rats

  AUTHORS: Mehdi Mahmoodi, Sadegh Zarei, Mohsen Rezaeian, Mohammad Kazemi Arababadi, Hassan Ghasemi, Hossein Khoramdelazad, Naser Rezayati, Gholamhossein Hasanshahi, Seyed-Mostafa Hosseini-Zijoud

  KEYWORDS: Persian Shallot; Glucokinase; Gene Expression; Diabetes

  JOURNAL NAME: American Journal of Plant Sciences, Vol.4 No.7, July 5, 2013

  ABSTRACT: Hepatic GCK is a key enzyme in glucose homeostasis and, as such, is a potential target for treatment strategies of diabetes. We investigated the effect of Persian shallot (Allium hirtifolium Boiss) hydroalchoholic extract on blood glucose level, plasma insulin level, GCK activity and its gene expression. Thirty two male rats were divided into 4 groups of 8, diabetic groups received 100 and 200 mg/kg Persian shallot extract, diabetic control and normal control received 0.9% saline for 30 days. Investigations of gene expression by Real-Time PCR showed that Persian shallot had led to gently increased GCK gene expression in diabetic rats. GCK activity increased significantly in Persian shallot treated group in dose dependent manner (P