TITLE:
Multifocal Malignant Lymphoma of the Breast
AUTHORS:
Elmas Ozgun, Deniz Tuncel, Ayca Tan, Aynur Albayrak, Sehnaz Sayhan, Nurten Bozlak
KEYWORDS:
Lymphoma; Breast; Multifocal
JOURNAL NAME:
Open Journal of Pathology,
Vol.3 No.3,
June
28,
2013
ABSTRACT: Primary non-Hodgkin’s lymphomas is an
uncommon disease representing approximately 0.13% of all reported malignant
mammary neoplasms. Clinically they are mainly observed as solitary lesions, but may
also be seen as multiple foci. Herein, we present a very rare case with the
diagnosis of multifocal malignant lymphoma of the breast. Case: A 56-year-old-female
patient with a right palpable breast mass admitted to the hospital. Mammography
and ultrasonography findings showed two different foci of hypoechoic solid mass
forming lesion in the right breast. Excisional biopsy has been performed. In
the histopathological evaluation, both lesions demonstrated foci of necrosis;
mitotically active tumor cells with large nucleus and prominent nucleoli. The immunohistochemical
analysis revealed diffuse LCA, CD20, CD43, focal CD68 positivity while
pancytokeratin, EMA, CD34, SMA were negative. The case was diagnosed as Diffuse
Large B-cell Lymphoma. We report a very rare case with a diagnosis of
multifocal primary non-Hodgkin’s lymphoma of the breast.