TITLE:
Pleomorphic Adenoma with Exuberant Squamous Metaplasia and Keratin Cysts Mimicking Squamous Cell Carcinoma in Minor Salivary Gland
AUTHORS:
Sharon Lim, Inju Cho, Jun-Hee Park, Sung-Chul Lim
KEYWORDS:
Pleomorphic Adenoma; Squamous Metaplasia; Keratin Cyst; Squamous Cell Carcinoma; Salivary Gland
JOURNAL NAME:
Open Journal of Pathology,
Vol.3 No.3,
June
28,
2013
ABSTRACT: Salivary
gland tumors, the second most common neoplasm of the mouth after squamous cell
carcinoma, account for a significant proportion of tumors of the oral and
perioral regions. An unusual case of adenoma presented as a solitary intraoral
palatine mass in a 32-year-old woman is reported here. The tumor was
interpreted as an unusual pleomorphic adenoma because of the presence of
exuberant squamous metaplasia, clinically mimicking squamous cell carcinoma.
Moreover, the presence of cystic structures filled with keratinized material
was also salient feature. Pleomorphic adenomas may occasionally display focal
squamous metaplastic changes; when extensive, it presents the potential for misinterpretation
of the histology as indicative of well-differentiated squamous cell carcinoma.